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New Diagnostics in Tuberculosis: Interferon - page 5 / 38

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Tuberculin Skin test

z False positive tests occur because of previous BCG vaccine or exposure to non tuberculous mycobacteria.

z False negatives occur because of T cell mediated immune deficiency due to drugs or disease.

z Up to 30% of patients with active TB will have a negative skin test making it poor for diagnostic purposes.

z Administered intradermally and then read in 48-72 hours requiring the patient to return for a reading.

z Both administration and the reading itself requires skill to be performed correctly.

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