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Fish Consumption Advice for Alaskans

Table 7. Guidelines Derived by Various Agencies for Acceptable Mercury Intake Levels

Corr. To Hair

1

Corr. To Blood

1

Explanation for Safety Factor

Safety Factor

Acceptable Daily Intake Level

(ug/kg BW/day)

Population

Primary Study

NOAEL

Agency

2.2 ppm

8.7 ppb

3.2 – inter-individual variability in dose reconstruction 2 – variability in blood/hair ratio

6.4

0.22

WCBA and children

Used results of Faroes (NOAEL 12 ppm) AND Seychelles (NOAEL 15.3 ppm)

14 ppm hair

JECFA (FAO/WHO)

5.2 ppm

22 ppb

10

0.5

all other adults

Japanese data

52 ppm hair (LOAEL)

JECFA (FAO/WHO)

3 – pharmaco variability 1.5 – temp lack of certain tests pharmaco variability *reasonable change; domain-specific tests now available

4.5

3*

0.3

0.4*

Not adopted by ATSDR

Seychelles

Seychelles

15.3 ppm

ATSDR (U.S.)

ATSDR (U.S.)

1.2 ppm

5.8 ppb

10

0.1

Faroes – lower 95% CL on the BMD (58 ppb)

85 ppb blood benchmark dose

U.S. EPA

LOC 20 – 100 ppb Action >100 ppb

inter-individual variability

5

0.2

WCBA and children

10 ppm hair

Health Canada

20 ppb

10

0.5 0.5

all other adults all other adults

Japanese data

200 ppb blood (LOAEL)

Health Canada U.S. FDA

1 = "Acceptable" blood and/or hair levels expected to correspond to the acceptable daily intake level U.S. EPA = United States Environmental Protection Agency JECFA = Joint FAO/WHO Expert Committee on Food Additives (FAO/WHO) ATSDR = Agency for Toxic Substances and Disease Registry U.S. FDA = U.S. Food and Drug Administration WCBA = Women of childbearing age LOAEL = Lowest observed adverse effect level NOAEL = No observed adverse effect level LOC = Level of concern BMD = Benchmark dose

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