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MARIJUANA (p.1)

  • 1.

    Tetrahydrocannabinol (THC) active ingredient in marijuana (MJ) now classified as an anadamide partial agonist (ligand) 420+ ingredients in smoke from MJ psych. active ingredients include THC, cannaninol, & cannabidiol (cannabinoids – synthetic THC mimics)

  • 2.

    Anandamide 1992 ligand was isolated prior to 1992 MJ had been classified as a mild sed-hyno, sort of = to BZDs or ETOH

although even high doses of MJ do not suppress respiration, not lethal little cross-tolerance with GABA agonists

3. Unique Effects decreased attention span decreased STM changes in sensory awareness analgesia decreased Sxs of RA decreased nausea, vomiting

decreased motor control increased appetite (?) increased bronchodilation decreased body temperature decreased libido & sperm count(hi dose) decreased fertility (hi doses)

decreased androgens (secondary gyncomastia at hi doses)

4. Mechanisms of Action THC --- indirectly inhibits adenylene cyclase adenylene cyclase involved in G-protein 2nd messenger RSs which normally --- influx of Ca++ and efflux of K+ with this pathway inhibited, there is less release of NTs from presynaptic axon terminals THC --- also decrease release of glutamate in hippocampal neurons --- ?

there are many anandamide RSs in CNS, maybe 10-20x the # of opioid RSs may be tied with GABA as most numerous RSs (= 1/3 of all RSs)

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