5. Major CNS Areas with THC Effects hippocampus (--- decreased STM) cerebral cortex (esp. frontal lobes) (--- attention span, distorted sensory perceptions) cerebellum & basal ganglia (decreased motor performance) spinal cord (--- analgesia) “none” in brainstem (medulla) (no effect on respiration, heart) but must have some effect on medulla…why?
Major PNS Areas & Others with THC Effects in PNS have both cannabinoid RS1s and RS2s RS2s are found in lymph cells (WBCs) (depressed I.S. functioning?) in heart, lungs, arteries, endocrine system, & reproductive organs increased HR, BP, vasodilation bronchodilation decreased sperm count, libido, gyncomastia
Pharmacokinetics ¼ to ½ of THC is available in smoke one MJ “joint” = 0.4 to 10 mg of THC into bloodstream (assuming 1gram of plant material & 50 mg of THC)
rapid onset of effects when smoke inhaled (about 5 seconds) bodily effects last about 3-4 hours when inhaled (e.g. effects on HR) but psych effects (“high”) can last 12+ hours
if taken PO, absorption is much slower and doses reduced 30-60 minute onset latency likely subject to 1st pass metabolism in liver
distributed through out body tissues, esp. into fat tissues (very fat soluble) easily crosses BBB & placenta