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MARIJUANA (p. 3)

7. Pharmacokinetics (cont.) THC is metabolized by P450 enzymes --- active metabolite --- inactive metabolite --- eliminated this process extends ½ life of THC to 30-60 hours thus, urine drug screens can be done for relatively long time after S MJ and still get a + result (2 to 14 days after, in acute user; 30 days for a chronic user…and even longer in an obese S)…why?

  • 8.

    Pharmacological Effects of THC

    • a.

      in non-human animals

mice – bred to lack cannabinoid RSs --- higher mortality rates, decreased activity levels, increased sensitivity to pain

cannabinoids potentiate morphine-induced analgesia THC --- decreased release of substance P, decreased release of glutamate --- decreased pain signals

  • ---

    increased activity in “opiate” RSs --- decreased pain

THC --- potentiates sed-hypn effects decreased aggression decreased seizures (increased seizure threshold) increased reaction times, decreased reflexes decreased motor performance on complex tasks increased hallucinations/sensory distortions (of time, audition, color, taste) increased social interactions increased eating at high doses --- decreased ovulation, decreased sex hormones, decreased sperm, decreased fertility

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