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ZARATE JO, et al.

Fig. 1: Clinical characteristics of the white nodular lesion in the limbar conjunctiva.

Fig. 3: Multinucleated giant cells distributed in the stro- ma.

and 7 of the clock in the RE. The lesion was accom- panied by a moderate perilesional conjunctival injection. The LE did not exhibit pathological alte- rations. The assessment of the posterior segment was normal in BE. Intraocular pressure (IOP) was of 12 mmHg in the RE and 14 mmHg in the LE, without evidence of lymphadenopathies.

The lesion was resected locally without compli- cations for subsequently biopsy. Macroscopically it was a circumscribed but not encapsulated lesion with a firm but elastic consistency with regular whi- tish surface, without evidence of necrosis, hemorr- hage or calcification. Said lesion measured 0.9 x 0.5 x 0.2 mm. The sample was immersed in formol buf- fer 10% for histological examination, subsequent

inclusion in paraffin and coloring with Hematoxili- ne and Eosin, PAS and Masson trichromic. These studies revealed that the tumor consisted in a pro- minent hypocellular matrix comprising hyalinized collagen strips which adopted a storiform pattern. The strips exhibited numerous giant multinuclear cells with clear cytoplasm, without pleomorphism or nuclear Hyperchromatism or evidence of myco- tic figures. In addition, star-shaped cells were observed together with said giant cells, having an analogous nuclear morphology and distributed in isolated manner in the strioma. No necrosis areas, fibromixoid changes or calcifications were obser- ved.

Subsequently, the immunohistochemical (IHQ) studies were carried out using monoclonal cells in

Fig. 2: Storiform pattern of the hyalinized stroma (Mas- son’s trichromic).

Fig. 4: Vimentine expression in giant multinucleated cells.


ARCH SOC ESP OFTALMOL 2007; 82: 233-236

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