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Treatment of Schizophrenia (and Related Psychotic Disorders) - page 28 / 56

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Clozapine: pros and cons

Superior efficacy for positive symptoms

Possible advantages for negative symptoms

Virtually no EPS or TD

Advantages in reducing hostility, suicidality

Associated with agranulocytosis (1-2%)

WBC count monitoring required

Seizure risk (3-5%)

Warning for myocarditis

Significant weight gain, sedation, orthostasis, tachycardia, sialorrhea, constipation

Costly

Fair acceptability by patients

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