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Treatment of Schizophrenia (and Related Psychotic Disorders) - page 34 / 56

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Relapse Rates in 1 Year Studies: Atypical vs. Typical Antipsychotics

p=0.0001 in favor of atypical drugs; Leucht S et al. Am J Psychiatry. 2003

-0.5

0

0.5

Favors Conventional Drug

Favors Atypical Antipsychotic

Marder, 2002 (risperidone)

Csernansky, 2002 (risperidone)

Risperidone pooled

Daniel, 1998 (sertindole)

Speller, 1997 (amisulpride)

Tamminga, 1993 (clozapine)

Essock, 1996 (clozapine)

Rosenheck, 1999 (clozapine)

Clozapine pooledd

Tran, 1998a (olanzapine)

Tran, 1998b (olanzapine)

Tran, 1998c (olanzapine)

Olanzapine pooled

Total

2/336%3/3010%

41/1772365/18835

43/2102168/21831

2/94212/10911

5/29179/3129

1/2540/140

13/761715/4831

10/35294/1429

24/1361819/7625

10/45222/1020

6/48133/1421

71/5341329/15619

87/6271434/18019

161/109615142/61423

Risk Difference (95% CI fixed)

NACA

n/N%n/N%  

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