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PBC and PSC

PBC: Diagnosis

liver biopsy

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gold standard to make diagnosis and exclude other diagnoses

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stage 1 - portal triad inflammation

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stage 2 - parenchymal (interface) hepatitis

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stage 3 - fibrosis

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stage 4 – cirrhosis

imaging studies

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main utility in excluding biliary obstruction

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can see increased hepatic echogenicity

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can see lymphadenopathy in 25%

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