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PBC and PSC

PBC: Treatment

traditional glucocorticoids

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one controlled trial with benefits on biochemistry and histology

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no change in mortality

colchicine

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in 3 controlled trials, no prognostic or survival benefit

azathioprine

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248 patients without biochemical, histologic or survival benefit

cyclosporine

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349 patients without histologic or survival benefit

methotrexate

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only one controlled trial with worse outcomes at 6 years

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