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PBC and PSC

PBC: Transplantation

survival is better if transplanted before a life-threatening complication or patient is on life support

common indications

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portal hypertensive bleeding

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refractory ascites

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encephalopathy

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hepatorenal syndrome

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disabling fatigue

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disabling pruritus

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severe muscle wasting

one-year survival rates 90%; 5-year >80%

post-transplant recurrence (by biopsy) in 30-50% by 10 years but usually takes a benign course

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