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PBC and PSC

PSC: Epidemiology

prevalence of 6-8 per 100,000

up to 44% are asymptomatic at diagnosis

80% of patients have concomitant IBD and 90% of those have ulcerative colitis (some years before symptoms)

3-6% of UC patients and 1% of Crohn’s patients have PSC

PSC and IBD progress independently

median age at diagnosis is 39 (neonates to octogenarians)

male:female ~ 1.5:1

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