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PBC and PSC

PSC: Diagnosis

symptoms

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high index of suspicion in IBD patients

physical findings

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hepatomegaly

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splenomegaly

laboratory

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alkaline phosphatase elevation (usually 3-fold or higher)

6% have normal alkaline phosphatase

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modest transaminase elevations (usually < 3-fold)

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bilirubin may be normal

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small subset have marked eosinophilia

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65-85% are ANCA positive

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