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PBC and PSC

PSC: Natural History and Prognosis

median survival or time to transplant is 12 years, but very variable and less predictable than PBC

some predictors of poor prognosis (Mayo model)

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advanced age

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degree of bilirubin elevation

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low albumin

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high AST level

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variceal bleeding

Child-Pugh classification is used by UNOS (transplant listing)

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class A: 90% 7 year survival

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class B: 68% 7 year survival

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class C: 25% 7 year survival

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