X hits on this document

86 views

0 shares

0 downloads

0 comments

6 / 34

PBC and PSC

PBC: Pathogenesis

cause or trigger remains unknown (alloantigen?)

immune (T-cell) mediated attack that targets the epithelial cells of interlobular bile ducts

see B-cell elaboration of autoantibodies that may not be pathogenic

-

AMA is not pathogenic

intrahepatic bile duct destruction leads to cholestasis and fibrosis

Document info
Document views86
Page views86
Page last viewedTue Jan 17 08:03:31 UTC 2017
Pages34
Paragraphs559
Words1582

Comments