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Activation of the cerebellum in co-ordinated eye and hand tracking movements: an fMRI study - page 7 / 12

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Fig. 4A–H Contrast of all tracking conditions versus rest (tasks A, B, C vs. D; experi- ment 1). Strong activation was observed in visual cortical areas (A, B) and very signifi- cant activation seen in the ipsi- lateral hemisphere (ansiform lobule) of the cerebellum (C), vermis (D–E) and paramedian lobule (F, G)

Vermis

<0.001

8.67

–2

–62

–12

Ansiform

<0.001

8.88

–20

–45

–17

Contra Ansi.

<0.001

7.76

25

–46

–17

Paramedian

<0.001

8.55

–17

–63

–40

Occipital

<0.001

970

<0.001

8.42

–11

–65

8

Vermis

<0.001

1137

<0.001

8.43

–9

–49

–5

Vermis

<0.0001

7.26

–2

–70

–19

Ansiform

<0.001

8.41

–20

–45

–17

Paramedian

0.001

8.20

–17

–63

–40

Contra Ansi.

0.001

115

<0.001

6.68

29

–41

–27

Contra Ansi.

<0.001

6.64

25

–46

–17

Ansiform

<0.001

1258

<0.001

8.53

–9

–49

–5

Ansiform

<0.001

8.32

–20

–45

–17

Vermis

<0.001

8.15

–2

–62

–12

Paramedian

<0.001

8.00

–17

–63

–40

Ansiform

<0.001

500

<0.001

6.26

–15

–47

–6

Vermis

<0.002

52

<0.001

5.91

–3

–67

–20

Experiment

Conditions (contrast)

Lobule

Cluster P*

Voxels

Voxel P**

Max Z

X

Y

Z

1

All movement (tasks A, B, C vs. D)

Ansiform Ansi./Vermis

<0.001

1581

<0.001 <0.001

7.90 7.82

–20 –9

–45 –49

–17 –5

1

Main effect: hand (tasks A, C vs. B, D)

Vermis

<0.001

1466

<0.001

8.98

–9

–49

–5

Ansiform

0.003

5.26

–15

–45

–17

2

Eye movement (task B vs. A)

Paramedian

0.021

35

0.001

5.54

–15

–49

–44

Table 2 Functional activation of cerebellar sites during eye and hand tasks: regional activation clusters characterised by the vol- ume of each region (k), its significance based on spatial extent P(nmax>k), the highest Z value (u), its corrected significance P based on P(Zmax>u) and the location of this primary maximum. Up to three secondary maxima (light font) are included for each major region (bold font) with their associated significance based

on the corrected P values. The co-ordinates given are in milli- metres, calculated from the voxel location of the peak; these are approximately equivalent to Talairach and Tournoux (1988) co-ordinates, following a rigid body rotation and translation of the normalised images shown in the figures. Ansi. Ansiform lobule, Post Ansi. posterior ansiform lobule, Paramedian paramedian lobule with possible involvement of biventer lobule

Ansiform

0.000

6.26

–30

–51

–25

Vermis

0.000

6.48

6

–61

–22

Paramedian

0.033

19

0.003

5.33

19

–33

–39

s002210000489

1 1

Main effect: eye (tasks B, C vs. A, D) Hand movement alone (task A vs. D)

1

Co-ordinated hand movement (task C vs. B)

1

Coordinated eye and hand movement (task C vs. A, B)

0.002

5.35

–3

–67

–30

0.225

4.30

15

–61

–41

0.290

4.22

–18

–33

–39

0.429

4.08

–11

–38

–37

<0.001

3.79

4

  • 63

8

Vermis

Post. Ansi.

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