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Causes of Hypothyroidism in Adults

z Usually due to malfunction of thyroid itself

z Principle cause of thyroid dysfunction is chronic autoimmune thyroiditis

z Other causes include insufficient iodine in the diet, surgical removal of thyroid, and destruction of the thyroid by radioactive iodine

z May also result from altered secretion of TSH

z Therapeutic Strategy: replacement therapy with thyroid hormones z Levothyroxine (T4) z Levothyroxine (T4) plus liothyronine (T3)

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