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Hypothyroidism Management Levothyroxine

z Half-life of about 7 days due to high

protein binding z Time to steady state is about one month, so

onset of full effects is delayed z Make dosage adjustments slowly z Long half-life permits once-a-day dosing

z Adverse Effects z Rare when administered at appropriate dosage z With excessive dosage, tachycardia, angina, tremor, insomnia, heat intolerance, sweating may occur

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