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Hypothyroidism Management Levothyroxine: Drug Interactions

z Drugs that reduce levothyroxine absorption z Cholestyramine, Sucralfate, Aluminum-containing Antacids z Separate administration of levothyroxine and these drugs by 3-4 hours

z Drugs that accelerate Levothyroxine Metabolism z Phenytoin, carbamazepine, setraline, phenobarbital z Patients taking these drugs may need to increase their levothyroxine dosage z Levothyroxine enhances the effects of warfarin z Thyroid hormones increase cardiac responsiveness to catecholamines

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