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Thyroid Hormones

z Thyroid hormones are released from the thyroid gland by a proteolytic process

z More than 99.5% of T3 and T4 in plasma are bound to plasma proteins

z Only a fraction of circulating thyroid hormone is free to produce biological effects

z Thyroid hormones are eliminated primarily by hepatic metabolism

z B e c a u s e T 3 a n d T 4 a r e e x t e n s i v e l y b o u n d t o p l a s m a p r o t e i n s , m e t a b o l i s m t a k e s p l a c e s l o w l y . T h u s T 3 a n d T 4 h a v e p r o l o n g e d h a l f - l i v e s z T 3 t 1 / 2 = 1 . 5 d a y s z T 4 t 1 / 2 = 1 w e e k )

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