Etiology of OCD
The neurobiological model has received widespread support in the past decade. OCD occurs more often in persons who have various neurological disorders, including cases of head trauma, epilepsy, Sydenham’s and Huntington’s chorea. OCD has also been linked to birth injury, abnormal EEG findings, abnormal auditory evoked potentials, growth delays, and abnormalities in neuropsychological test results. Recently, a type of OCD has been identified in children after a group A beta-streptococcal infection.
The most widely studied biochemical model has focused on the neurotransmitter serotonin because SRIs are effective in treating patients with OCD.
Brain imaging studies have provided some evidence of basal ganglia involvement in persons with OCD.