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TABLE 1- The Physical properties of the final formulation

Physical Properti Weight variation (mg)

es

Average weight (mg)

Thickness (mm)

Hardness (kg)-(core tablets) Friability (%)-(core tablets) Disintegration ( Min) Drug content (%)

Parameters Range 5.0 % (Between 2 .850 g and 3.150 g) 150.0 mg ± 5.0% (Between 142.5 mg and 157.5 mg) Between 2.70 mm to 3.20 mm

Between 6 to 12.5 Not more than 1.0 % w/w

Should not be more than 15 min Not less than 95.0 % and not more than 110.0 % of the labeled

Actual Parameters 2%

    • 151.4

      -152.0 mg

    • 2.89

      mm

    • 8.5

      kg

    • 0.2

      %

1 min 4 seconds 99.41 %

amount

of Carvedilol

The remaining 3 % was incorporated as extragranular portion during the lubrication process. The two step of addition of disintegrant is reported to produce more complete disintegration as

30 is an excellent and versatile all purpose binder with a concentration 3 -5 % of the dry mass during the wet granulation step. Magnesium stearate used as an anti- adherent and lubricant. Collidal silicon

Table 2- The detailed Processed Conditions

Tablet Composition

Coating dispersion composition

Processing conditions

Carvedilol, Povidone ( PVP 30), Lactose Monohydrate,

K PVA, Tween 80,Triethyl citrate, purified talc

Bed temperature 40-45

Colloidal silicon dioxide, Polyplasdone INF 10 (crospovidone) Magnesium stearate

Spray rate 5 g/min

Spray nozzle diameter 1mm

Spray pressure 4 kg/cm

Pan speed 20 rpm

T1

T2

T3

T4

0

0

0

0

0

5

28

46

34

33

10

51

74

54

52

20

70

83

71

70

30

78

88

77

78

45

85

92

86

87

60

86

96

87

88

Table 3- The dissolution profile of the coated tablets with different weight gain

Time (min)

pH 6.8 Phosphate Bu

ffer

the extragranular portion produces immediate disruption of the tablets in to the pre compressed granules. Intragranular portion produces further erosion of the granules to the primary particles. PVP-K

dioxide is used as a glidant. The physical properties are outlined in the Table 1.The core tablets passed the friability test as the friability of the core tablets was found to be within the specified limit of 1 %. The

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