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Opioids: Should Tolerance Affect our Management? - page 33 / 46

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Type of Pain (neuropathic vs. nociceptive)

 Rat studies demonstrate that neuropathic pain models may develop tolerance less rapidly than nociceptive pain models

 Human intrathecal morphine study found only a 1.2-fold increase in MS dose over 4 months in neuropathic/nociceptive pain and a 3.8-fold increase in MS dose for nociceptive only pain

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