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Opioids: Should Tolerance Affect our Management? - page 46 / 46

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Conclusion

1) Tolerance to opioids does occur, but the                         system is highly complex with many variables

2) We need to admit that opioid tolerance is a    significant issue so that we can critically analyze the system and find the “fragile” point(s)

3) Development of novel analgesics with less

tendency for tolerance development is critical,

especially for younger pain patients

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