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Antigenic Structure and Function Research Update – Cont.

Optimizing the Age and Schedule for Measles Immunization and Assessing the Persistence of Measles Immunity in Vaccinated Populations

Measles neutralizing antibody titers increase 2-3 fold after a second dose and return to baseline within 6 months of immunization.  In the post- elimination environment, titers decline steadily so that by age 30 (~25 years after dose 2), approximately 1/3 of the adult population can be expected to have antibody titers <120mIU/mL based on current models. (LeBaron, Beeler, et al., 2007.  Persistence of measles antibodies after 2 doses of measles vaccine in a postelimination. Arch Pediatr Adolesc Med. 2007 Mar;161(3):294-301)

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