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Influenza Virus Molecular Biology Research Update

Optimizing Influenza Vaccine Candidates by Modification of Specific Influenza Genes

Modify the NA gene of pandemic influenza vaccine candidates to increase virus yields

Adamo, et. al., 2009. Optimizing Viral Protein Yield of Influenza Strain A/Vietnam/1203/2004 by Modification of the Neuraminidase Gene. Journal of Virology, 83:4023-4029.

Studies being extended to address yields of A/California/07/2009-like viruses

Modify the M gene of A/PR8 donor virus to optimize virus yields

Enhanced association of M and NP improved replication of a low-yielding H3N2 strain

Studies being extended to address yields of A/California/07/2009-like viruses

Establish an animal model of pandemic H1N1 virus pathogenesis to evaluate the safety of pandemic vaccine candidates

Suggested age-dependent pathogenesis of pandemic H1N1 in the mouse model

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