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Influenza Virus Molecular Biology Research Update – Cont.

Support Influenza Vaccine Development and Production

Construct pandemic H1N1 vaccine candidates suitable for manufacture

Provided CBER-RG2 (pandemic H1N1) to over 20 WHOccs and manufactures worldwide

Ongoing studies to investigate antigenic stability after passage

Conduct  human serology studies to support WHO influenza vaccine strain selection

SH studies in Sept 2009/NH in Feb 2010

Evaluate a murine infection model to explore the mechanisms of cross-protection against pandemic influenza viruses

Xie et al 2009. A live attenuated H1N1 M1 mutant provides broad cross-protection against infleunza A viruses, including highly pathogenic A/Vienam/1203/2004 in mice. Journal of Infectious Diseases, 200:1874-83.

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