Influenza Pathogenesis and Immunity Research Update
Contribution of NA-specific Immunity to Influenza Vaccine Efficacy
Develop practical assays to measure functional NA-specific antibody titers
Sandbulte et al. A miniaturized assay for influenza neuraminidase inhibiting antibodies utilizing reverse genetics-derived antigens. Influenza and other Respiratory Viruses 3: 233-240, 2009
Hassantoufighi et al. A Practical Influenza Neutralization Assay to Simultaneously Quantify Hemagglutinin and Neuraminidase-Inhibiting Antibody Responses. Vaccine 28:790-797, 2010
Evaluate role of NA-specific antibodies/inhibitors in selection of escape variants
Memoli et al. Rapid selection of a transmissible multi-drug resistant influenza A/H3N2 virus in an immunocompromised host. J Inf Dis, in press.