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Influenza Pathogenesis and Immunity Research Update – Cont.

Cell Mediated Immunity to Influenza

Develop practical assays to evaluate cell-mediated immunity

Eichelberger et al. Comparison of Human Immune Responses to Live , Attenuated and Inactivated Influenza Vaccines. In preparation

Studies are in progress to evaluate human CD4+ T cell responses to pandemic 2009 H1N1 infection and vaccination

Characterize early factors that initiate cell mediated immunity

Harris et al. Intramuscular immunization of mice with live influenza virus results in robust antibody and CD8+ T cell responses. In preparation.

Studies are in progress to compare early inflammatory responses to pandemic 2009 H1N1 and other H1N1 viruses in mice

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