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of the research conducted in the past year, a table detailing the numbers and species used, and a statement assuring the committee that the investigator is familiar with the definition of significant changes, and that no such changes have occurred. A significant change includes, but is not limited to, using a different species, an increase in numbers, or the addition of any procedure that may increase pain, distress, or discomfort.


After the third report is submitted (end of year three), the principal investigator must submit a new protocol form, and have the procedures reviewed again, as if it were a new protocol.


If the IACUC refuses to approve the use of animals in an ongoing research project, the IACUC will provide the investigator with a statement as to the reasons for the disapproval, and if necessary will make recommendations for changes in the proposed animal care and use which would lead to approval by the IACUC.


Be authorized to suspend an activity involving animals as set forth in the PHS Policy at IV.C.6. The IACUC procedures for suspending an ongoing activity are:  


If the IACUC becomes aware of activities with animals that are conducted without the IACUC’s approval, or that are being conducted in such a way as to endanger the health or well being of animals or humans involved in the animal research, the IACUC will immediately contact the PI and request clarification in writing. Upon receipt of the PI’s written account, the IACUC will convene an emergency meeting to discuss possible suspension of activities with animals. Official suspension of activity involving animals can occur only after a majority vote of the quorum of the IACUC members present at the meeting. Following the vote, the IACUC will notify the Institutional Official of its decision in writing, and verify that the unauthorized activity has ceased. The IO, in consultation with the committee, will then review the reasons for the suspension, and take appropriate corrective action, and report the action, and full explanation to OLAW.

The individual(s) authorized by this institution to verify IACUC approval of those sections of applications and proposals related to the care and use of animals is Dr. Eric S. Murphy, Chair IACUC or Dr. Jackie Frederickson, DVM.

The occupational health and safety program for personnel who work in laboratory animal facilities or have frequent contact with animals is administered jointly by the IACUC and the Environmental Health and Safety / Risk Management Department at UAA and incorporates the following elements.

1. Hazard and Risk Assessment for each protocol is carried out by UAA’s EHS/RM Department, the IACUC, and the PI involved in the research. For example, the Director from UAA’s EHS/RM Department sits on the IACUC as an ex officio member and evaluates all protocols, participates in semi-annual program evaluations and inspections, to assess potential hazards and risks to employees and research personnel (e.g.,


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