X hits on this document

Powerpoint document

Clevidipine Phase III Studies: Perioperative Hypertension - page 17 / 65

218 views

0 shares

0 downloads

0 comments

17 / 65

Treatment Protocol

Clevidipine

Initiated at 0.4 mcg/kg/min in pre-op, intra-op, or post-op setting

Titrated every 90 seconds in doubling increments up to 3.2 mcg/kg/min; infusion rates above 3.2 mcg/kg/min guided by patient response and permitted in serial increments of 1.5 mcg/kg/min.

Infusion rates between 4.4-8.0 mcg/kg/min were administered for no longer than 2 hours

Titration to higher infusion rates up to the maximal infusion rate of 8.0 mcg/kg/min was required before switching to or adding alternative antihypertensive drugs.

May continue through discharge from ICU

Target blood pressure – as deemed appropriate by the study physician

Comparators – dosed as per institutional practice

Nitroglycerin

Sodium nitroprusside

Nicardipine (post-operative only)

Aronson S et al. Anesth Analg 2008 (in press)

Document info
Document views218
Page views218
Page last viewedSun Dec 11 04:57:11 UTC 2016
Pages65
Paragraphs1351
Words4734

Comments