X hits on this document

Powerpoint document

Clevidipine Phase III Studies: Perioperative Hypertension - page 18 / 65

215 views

0 shares

0 downloads

0 comments

18 / 65

Methods

Descriptive analytical methods

Prespecified safety analysis by treatment received

Pooled data for clevidipine and all comparator arms

Prespecified analyses of clevidipine versus each comparator

BP Control assessed as the summation of integrated SBP vs time curve excursions

SBP plotted versus time from study drug initiation to arterial line removed or 24 hours, whichever came first

Pre-determined target SBP range

-

65-135 mm Hg intra-operatively

-

75-145 mm Hg pre- and post-operatively

AUC = magnitude (mm Hg) x duration (minutes) of SBP outside range

AUC normalized per hour and expressed as mm Hg x min/hr

Aronson S et al. Anesth Analg 2008 (in press)

Document info
Document views215
Page views215
Page last viewedSat Dec 10 20:28:14 UTC 2016
Pages65
Paragraphs1351
Words4734

Comments