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Clevidipine Phase III Studies: Perioperative Hypertension - page 38 / 65

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Post-Hoc Logistic Regression Results: Predictors of 30-day Renal Dysfunction

P-Value

Odds Ratio

95% CI

[Lower Limit, Upper Limit]

Pre-op serum Cr ≥1.2 mg/dl

<0.0001

5.466

3.506, 8.521

Pre-op hemoglobin (g/dL)

<0.0001

0.785

0.699, 0.881

Body mass index

0.0074

1.049

1.013, 1.087

Surgery duration (hour)

0.0077

1.292

1.070, 1.559

Age (year)

0.0086

1.033

1.008, 1.059

BP (4th quartile of AUC*)

0.0126

1.785

1.132, 2.815

Race (African American)

0.0151

2.164

1.161, 4.035

Primary CABG + valve

0.0165

1.944

1.129, 3.348

Aronson S et al. American College of Cardiology 56th Annual Scientific Session. March 2007. New Orleans, LA

*Total AUC of the magnitude and duration of SBP excursions outside the range of 85-145 mmHg pre- and postoperatively, and 75-135 mmHg intraoperatively; patients with AUC ≥75th percentile analyzed.

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