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Clevidipine Phase III Studies: Perioperative Hypertension - page 4 / 65

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ESCAPE Protocol

Clevidipine dosing

0.4 mcg/kg/min (approximately 2 mg/hr for an 80 kg. patient)

Dose doubled every 90 seconds until BP decreased by 15% or more

Once dose of 3.2 mcg/kg/min reached,  could increase by 1.5 mcg/kg/min increments to maximum of 8 mcg/kg/min

Identical placebo

Drug continued for at least 30 minutes, up to 1 hour

D/C at induction of anesthesia for ESCAPE-1

If target BP not reached at maximal dose, deemed treatment failure

Levy JH et al. Anesth Analg. 2007;105:918-925

Singla N et al. Anesth Analg. 2008;107:59-67

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