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Clevidipine Phase III Studies: Perioperative Hypertension - page 40 / 65

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Primary Endpoint Conclusions

Clevidipine demonstrated similar 30 day outcomes (Death, MI, Stroke, Renal Dysfunction) in a pooled analysis with comparator treatments (NTG, SNP, NIC).

Clevidipine demonstrated similar 30 day outcomes when compared individually with NTG and NIC in all components of the primary endpoint

When compared with SNP, Clevidipine demonstrated a significant mortality advantage, with similar outcomes in the remaining endpoint components

In post hoc analyses, clevidipine demonstrated improved blood pressure control compared to NTG and SNP as measured by 24 hour median AUC

BP control with clevidipine was comparable to nicardipine as measured by AUC

Excursions outside a targeted BP range are correlated with 30-day mortality and renal dysfunction

Future analysis of this post-hoc finding is warranted

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