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Clevidipine Phase III Studies: Perioperative Hypertension - page 44 / 65

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Prompt, but smooth reduction in BP

Reduce BP by ≤ 25% during the first minute to 1 hour

If stable, reduce BP in next 2-6 hours

Gradual reductions toward normal BP over next 24-48 hours

Exceptions requiring special care: ischemic stroke, stroke eligible for thrombolytic agents, aortic dissection

Avoid excessive drops in BP

May cause renal, cerebral or coronary ischemia

Need careful and close monitoring

Use of an arterial catheter for monitoring BP routinely required

Choice of pharmacologic agent should be tailored to patient

Based on risks, comorbidities and type of end-organ damage

Chobanian AV, et al. Hypertension. 2003;42:1206-1252.

VELOCITY: Rationale

Treatment Goals for Hypertensive Emergency

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