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Clevidipine Phase III Studies: Perioperative Hypertension - page 46 / 65

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VELOCITY: Design and Methods

Prospective, open-label, single-arm evaluation

Population: patients 18 years or older presenting to ED or ICU with severe hypertension (SBP >180 mm Hg or DBP >115 mm Hg) assessed at 2 successive occasions 15 min apart at baseline

Selection of SBP Target Range (TR) was determined prior to the initiation of clevidipine for each individual patient, with a range of 20-40 mm Hg from upper to lower limit

Dosing: clevidipine was initiated at 2 mg/hr and titrated to achieve TR:

during initial 30 min in doubling increments every 3 min to a maximum of 32 mg/hr

continued for a total duration of 18-96 hrs.

If TR not achieved in first 30 min, use of additional IV anti-hypertensives permitted

Annals of Emergency Medicine - 06 June 2008 (10.1016/j.annemergmed.2008.04.025)

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