at regular intervals. Tinnitus participants displayed a blunted cortisol response to psychosocial stress, in comparison with healthy controls who had a typical cortisol release about 30 min after the beginning of the experiment. The blunted cortisol response displayed by the tinnitus participants suggests that they have an anomaly along the HPA axis. Their cortisol response is similar to that found in other bodily stress-related diseases and thus suggests that tinnitus is related to stress. However, tinnitus intensity might not be modulated by stress in a concurrent manner.
Suppression of verbal hallucinations and changes in regional cerebral blood flow after intravenous lidocaine: a case report. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30;31(1):301-303. Plewnia C, Bischof F, Reimold M Department of Psychiatry and Psychotherapy, University of Tuebingen, Osianderstrasse 24, D-72076 Tuebingen, Germany. email@example.com
Simple and complex auditory phantom-perceptions such as tinnitus and musical hallucinations occur predominantly in elderly subjects and are often associated with hearing impairment. Isolated verbal hallucinations without other psychotic features are rare. It has been shown that an intravenous (i.v.) in- jection of lidocaine can transiently suppress tinnitus. Here we present the case of a 74 year old left-han- ded women with severely distressing, continuous verbal auditory hallucinations without other psychotic features. I.v. injections of 100 mg lidocaine but not saline resulted in substantial transient suppressions of the hallucinations for several hours. Using [(15)O]H(2)O positron-emission tomography (PET) decreased regional cerebral blood flow associated with reduced perception of voices was found in the right angular and supramarginal gyrus, right inferior frontal gyrus, orbitofronal cortex and in major parts of the cingula- te cortex. These data suggest to further investigate the clinical relevance of i.v. lidocaine in patients with therapy-resistant verbal hallucinations, support the notion of common pathophysiological mechanisms in different forms of auditory phantom-perception and demonstrate the feasibility of a new strategy for imaging studies on auditory hallucinations.
Time course of recovery of spontaneous activity (SA) in the rat inferior colliculus (IC) following unilateral acoustic trauma (Abstract of ARO Meeting Denver, Colorado) Thomas Imig1, Henry Heffner2, Gim Koay2, Dianne Durham1 1Kansas University Medical Center, 2University of Toledo
SA in the IC of rats was measured following unilateral acoustic trauma (isoflurane anesthesia, continuous 16 kHz tone for 60’, 115 – 120 dB SPL). At various times following sound exposure, unanesthetized rats were injected with C14 labeled 2 deoxyglucose (2DG) and placed in a quiet sound isolation chamber during uptake. Groups of 4 rats each received 2DG at different times following exposure (4 hour, 1, 2, 4, 8, 16 day, and control). Optical density (OD) measures were obtained from autoradiographs at 10 equally spaced segments that crossed the tonotopic axis of the central nucleus (ICc) and the external nucleus (ICx). OD for corresponding segments of ipsi and contra IC were compared and showed the following results: 1. OD was bilaterally symmetrical in controls. In exposed rats the contra IC showed a decrement in OD with respect to the ipsi IC at each survival time. Acoustic trauma did not cause an increase in OD at any survival time. 2. SA in contra IC showed partial recovery over time. The greatest decrement in OD was seen at 4 hours with lesser decrements at longer times. 3. Recovery of SA followed different time courses in the ICx and ICc. The decrement in OD extended throughout both the ICc and ICx at four hours. By 2 days, ICx showed full recovery (bilaterally symmetrical OD) but recovery in the contra ICc continued over an 8 day period. 4. Recovery of SA in the ICc showed a low (LF) to high frequency (HF) progression. In 4 h and 1 day groups, SA was decreased throughout the ICc with the greatest decrement
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