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Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings - page 19 / 62

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Inflammatory Response: Phagocytic Mobilization

  • Soon after inflammation, phagocytes (neutrophils and macrophages) enter the damaged area

  • Four main phases:

    • Leukocytosis – neutrophils are released from the bone marrow in response to leukocytosis-inducing factors released by injured cells (3hrs. Results in 4-5x increase)

    • Margination – blood flow slows to inflammed area

      • endothelial cells release cell adhesion molecules (CAMs), e.g. selectins, that serve as binding sites for the neutrophils’ CAM, e.g. integrein, molecules to bind and stop their movement thru the capillary

Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings

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