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Inflammatory Response: Phagocytic Mobilization

  • Four main phases (cont.):

    • Diapedesis – neutrophils leave the capillary (emigration)

    • Chemotaxis – inflammatory chemicals act as chemotactic agents. Neutrophils follow chemicals to source upon which they destroy foreign materials found there.

      • Monocytes follow the neutrophils, swell in size and develop lysosomes and become macrophages and replace the neutrophils.

      • Macrophages remain at the site removing debris during prolonged chronic inflammation.

      • The goal is to remove pathogens, dead or damaged cells, debris so that the tissue can be repaired

Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings

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