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Complement Pathways

  • Complement can be activated by two pathways:

classical and alternative

  • Classical pathway is linked to the immune system

    • Depends on the binding of antibodies to invading organisms

    • Subsequent binding of C1 to the antigen-antibody complexes (complement fixation)

  • Alternative pathway is triggered by interaction among factors B, D, and P, interacting with polysaccharide molecules present on the surface of the microorganisms

Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings

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