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Antigenic Determinants

  • Only certain parts of an entire antigen are immunogenic

  • Antibodies and activated lymphocytes bind to these antigenic determinants

  • Most naturally occurring antigens have numerous antigenic determinants that:

    • Mobilize several different lymphocyte populations

    • Form different kinds of antibodies against it

  • Large, chemically simple molecules (e.g., plastics) have little or no immunogenicity

Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings

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