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Clonal Selection

  • A naive, immunocompetent B cell is activated when antigens bind to its surface receptors and cross-link adjacent receptors

  • Antigen binding is followed by receptor-mediated endocytosis of the cross-linked antigen-receptor complexes

  • These activating events, plus T cell interactions, trigger clonal selection

  • The B cell grows and multiplies from the original clonal cell

Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings

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