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Primary Response (initial encounter with antigen)

B lymphoblasts

Proliferation to form a clone

Plasma cells

Secreted antibody molecules

Secondary Response (can be years later)

Clone of cells identical to ancestral cells

Plasma cells

Secreted antibody molecules

Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings

Antigen

Antigen binding to a receptor on a specific B lymphocyte (B lymphocytes with non-complementary receptors remain inactive)

Memory B cell

Subsequent challenge by same antigen

Memory B cells

Figure 21.10

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