Food Allergen Tested
Lowest Dose Tested (mg proteina)
Responses at lowest dose tested?
LOAEL Observed (mg proteina, b)
Sign(s)s or symptom(s) used to determine LOAEL
Population Dose/Response Data
Perry et al., 2004
Milk, egg, peanut, soy, wheat
Scibilia et al., 2006
27 wheat allergic adults
Flour, raw and cooked
7 specified doses
Appendix 2: Evaluation of Available Allergen Oral Challenge Studies.
Note: Question marks (?) in the table indicate either that the information was not given or could not be determined.
a Calculated based on the following estimate protein levels: 16% in raw hazelnuts, 20% in fish meat, 3.6% in whole milk, 37.5% in dried milk, 25% in whole peanut, 45% in defatted peanut flour, 10% in egg white, 84% in dried whole egg , 26% in raw egg, 1.8% in soy formula (FAO, 1995; Wensing et al., 2002; Bindslev-Jensen et al., 2002). In studies involving fish, the amount of fish is given when there is insufficient information to calculate protein levels.
When responses are observed at the lowest dose tested, the reported LOAEL may not represent the lowest dose at which a reaction could occur. It is not clear if all children were tested with all allergens.
Revised Threshold Report
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