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Study

Published

Test Population

Food Allergen Tested

Test Material

Lowest Dose Tested (mg proteina)

Dose Progression

Responses at lowest dose tested?

LOAEL Observed (mg proteina, b)

Sign(s)s or symptom(s) used to determine LOAEL

Population Dose/Response Data

Perry et al., 2004

Yes

Not reported

Milk, egg, peanut, soy, wheat

Not reported

Not reported

Not reported

Not reported

Not reported

Not reported

No

Scibilia et al., 2006

Yes

27 wheat allergic adults

Wheat

Flour, raw and cooked

15

7 specified doses

Yes

15

Objective

Yes

Appendix 2: Evaluation of Available Allergen Oral Challenge Studies.

Note: Question marks (?) in the table indicate either that the information was not given or could not be determined.

a Calculated based on the following estimate protein levels: 16% in raw hazelnuts, 20% in fish meat, 3.6% in whole milk, 37.5% in dried milk, 25% in whole peanut, 45% in defatted peanut flour, 10% in egg white, 84% in dried whole egg , 26% in raw egg, 1.8% in soy formula (FAO, 1995; Wensing et al., 2002; Bindslev-Jensen et al., 2002). In studies involving fish, the amount of fish is given when there is insufficient information to calculate protein levels.

b c

When responses are observed at the lowest dose tested, the reported LOAEL may not represent the lowest dose at which a reaction could occur. It is not clear if all children were tested with all allergens.

Revised Threshold Report

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