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Hourihane

Yes

60 peanut

Peanut

Whole

? (Labial

4 defined

Yes

Not

et al.,

allergic

peanut

challenge)

doses

reported

Nelson et al., 1997

Yes

12 peanut allergic adults

Peanut

Defatted peanut

0.45

12 defined doses

Not reported

Not reported

Bellioni- Businco et al., 1999

Yes

26 milk allergic children

Milk

“Fresh” whole milk

“1 drop”

Not reported

3.65

Hebling et al., 1999

Yes

9 fish allergic adults

Fish

Cooked meat from 3 species of fish

50

4 specified levels

Yes

50

Study

Published

Test Population

Food Allergen Tested

Test Material

Lowest Dose Tested (mg

Dose Progression

Responses at lowest dose tested?

Hourihane et al., 1997a

Yes

14 peanut allergic adults, 8 reacted

Peanut

Peanut flour

proteina) 0.01

12 defined doses

No

Appendix 2: Evaluation of Available Allergen Oral Challenge Studies.

LOAEL Observed (mg proteina, b)

1997b

adults

0.1 2

Sign(s)s or symptom(s) used to determine LOAEL

Population Dose/Response Data

Subjective Objective

Yes

Objective

No

Subjective

No

Objective

No

Subjective and Objective

Yes

Zeiger et al., 1999

Yes

93 milk allergic infants and children, 13 reacted to soy

Soy

Formula

1 drop to

6 to 7

5 ml

doublings

No

522

Objective

No

Revised Threshold Report

Page 92 of 108

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