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Study

Published

Test Population

Food Allergen Tested

Test Material

Lowest Dose Tested (mg

Dose Progression

Otolani et al., 2000

Yes

86 hazelnut allergic adults

Hazelnut

Ground nuts

proteina) 224

Dose doubling, possibly 4 levels

Appendix 2: Evaluation of Available Allergen Oral Challenge Studies.

Sicherer et al., 2000

Yes

196 children with a variety of food allergiesc

Peanut

400 or 500

6 or 7

mg of

specified

food

levels

Not reported

Milk

Not reported

Egg

Not reported

Soy

Not reported

Fish

Not reported

Wheat

Not reported

Eggesbo et al., 2001

Yes

41 children with reported allergy, 5 tested by DBPCFC

Egg

Pancakes

260

Dose doubling until reaction or maximum dose

Not reported

No

Not reported

No

Not reported

No

Not reported

No

Not reported

No

Objective

No

Responses at lowest dose tested?

LOAEL Observed (mg proteina, b)

Sign(s)s or symptom(s) used to determine LOAEL

Population Dose/Response Data

Not reported

Not reported

Not reported

No

Yes

Yes

Not reported

Not reported

Not reported

Not reported

Not reported

260

No

Not reported

Not reported

Revised Threshold Report

Page 93 of 108

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