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Appendix 2: Evaluation of Available Allergen Oral Challenge Studies.

Egg

Whole or

Not

Not reported

Not

Not

Not reported

No

dried

reported

reported

reported

Fish

Minced

Not

Not reported

Not

200 mg of

Not reported

No

Study

Published

Test Population

Food Allergen Tested

Test Material

Lowest Dose Tested (mg proteina)

Dose Progression

Responses at lowest dose tested?

LOAEL Observed (mg proteina, b)

Sign(s)s or symptom(s) used to determine LOAEL

Population Dose/Response Data

Bock in Taylor et al., 2002

No

69 peanut allergic, 66 milk allergic, 91 egg allergic, 8 fish allergic patients

Peanut

Ground

Not reported

Not reported

Not reported

1.25

Not reported

No

Milk

Nonfat dried

Not reported

Not reported

Not reported

140

Not reported

No

Egg

Whole dried

Not reported

Not reported

Not reported

200

Not reported

No

Milk

Nonfat dried

Not reported

Burks and Christie in Taylor et al., 2002

No

10 peanut

Peanut

Peanut

allergic, 21

butter

Not reported

No

milk allergic, 25 egg allergic patients

Not

Not reported

Not

reported

reported

67

No

reported

reported

Not reported

Not reported

fish

100

Not reported

Revised Threshold Report

Page 95 of 108

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