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Appendix 2: Evaluation of Available Allergen Oral Challenge Studies.

Study

Published

Test

Food

Population

Allergen

Tested

15 milk allergic patients

Milk

6 peanut, 6 milk, 18 egg allergic patients

Peanut

Milk

Host in Taylor et al., 2002

No

Lack in Taylor et al., 2002

No

Hill in Taylor et al., 2002

No

Egg

Milk

100 patients each for peanut, milk, egg

Peanut

Egg

Moneret- Vautrin #1 in Taylor et al., 2002

No

28 peanut allergic, 6 milk allergic, 19 egg

Peanut

Whole

Not reported

Not reported

Raw white

Not reported

Not reported

Forumula

Not reported

Not reported

Test Material

Lowest Dose Tested (mg proteina)

Dose Progression

Peanut butter

Not reported

Not reported

Whole

Not reported

Not reported

Cooked white

Not reported

Not reported

Raw white

Not reported

Not reported

Ground

Not reported

Not reported

Ground

Not reported

Not reported

Responses at lowest dose tested?

LOAEL Observed (mg proteina, b)

Sign(s)s or symptom(s) used to determine LOAEL

Population Dose/Response Data

Not reported

6

Not reported

No

Not reported

0.6

Not reported

No

Not reported

2

Not reported

No

Not reported

75

Not reported

No

Not reported

125

Not reported

No

Not reported

150

Not reported

No

Not reported

10

Not reported

No

Not reported

20

Not reported

No

Not reported

1.25 (single blind)

Not reported

No

2.5

Revised Threshold Report

Page 96 of 108

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