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Study

Published

Test Population

Food Allergen Tested

Test Material

Lowest Dose Tested (mg

Dose Progression

Wensing et al., 2002b

Yes

26 peanut allergic adults

Peanut

Roasted peanut meal

proteina) 0.030

10 specified doses

Fiocchi et al., 2003

Yes

18 children with allergy to both milk and soy

Milk

Whole

43.2

4 specified doses

Soy

Formula

21.8

Hansen et al., 2003

Yes

17 hazelnut allergic adults

Hazelnut

Raw and roasted nuts

Not reported

Not reported

Morisset et al., 2003

Yes

Undefined

Peanut

Crushed

1.25

5 specified levels

Oil

Not reported

Lactose free

0.36

Raw white Oil

0.2

Not reported

Pasteurized whole egg

2.9

Appendix 2: Evaluation of Available Allergen Oral Challenge Studies.

8 specified doses

Osterballe and Bindslev- Jensen, 2003

Yes

Milk

Egg Soy

56 egg allergic children

Egg

Responses at lowest dose tested?

LOAEL Observed (mg proteina, b)

No

0.1

Yes

43.2

21.8

Not reported

32 – roasted

Yes

16 – raw 1.25

No

Not reported

Yes

0.36

Yes No

0.2

Not reported

Yes

2.9

Sign(s)s or symptom(s) used to determine LOAEL

Population Dose/Response Data

Subjective and Objective

Yes

Objective

Yes

Objective

Oral allergy syndrome

No

Objective

No

Objective

No

Objective

No

Objective Objective

No No

Objective

No

Revised Threshold Report

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